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In this episode, Dr. Paul Yi, Associate Member, Department of Radiology, Director of Intelligent Imaging Informatics (I3) at St. Jude Children's Research Hospital, shares his journey from radiology training at Johns Hopkins to leading AI initiatives at St. Jude, focusing on pediatric cancer and other catastrophic diseases.
Dr. Yi highlights how AI is transforming the radiology workflow, from automating imaging protocols and improving image reconstruction to translating complex medical reports into patient-friendly language. He emphasizes the importance of data strategy, discussing the integration of clinical EMRs, PACS, and research databases, ensuring interoperability while leveraging domain expertise across disciplines. He explores generative AI applications, including virtual imaging trials that simulate patient populations for safer, faster, and cost-effective clinical research, as well as patient-facing applications like AI chatbots for healthcare education, noting both potential and limitations in trust and accuracy.
Dr. Yi reflects on bridging research and commercialization, underscoring the need to align academic and industry incentives. He envisions a future powered by multimodal AI models that combine imaging, vitals, labs, and clinical text to deliver comprehensive, personalized insights - accelerating precision care and innovation in pediatric oncology. Take a listen.
About Our Guest
Paul Yi, MD is an Associate Member, Department of Radiology and Director of Intelligent Imaging Informatics (I3) at St. Jude Children's Research Hospital. Dr. Yi is a practitioner of diagnostic imaging. The field of radiology and diagnostic imaging has been a proving ground for medical applications of artificial intelligence for a number of years. As a physician-scientist, Dr. Yi’s research interests include the development and application of AI and deep learning towards medical imaging applications, with special interest in evaluating the trustworthiness and fairness of deep learning models.
About the Host
Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.
Rohit is skilled in business and IT strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a Wharton School Fellow and a graduate from the Harvard Business School.
Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has previously also worked with IBM and Wipro. He completed his executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed the Global Healthcare Leaders Program from Harvard Medical School.
About the Legend
Paddy was the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor & Francis, Aug 2020), along with Edward W. Marx. Paddy was also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He was the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He was widely published and had a by-lined column in CIO Magazine and other respected industry publications.